Interview and Questionnaire Data are collected annually from all Clinical Core participants. Data collected include the National Alzheimer’s Coordinating Center's (NACC) Uniform Data Set (UDS). A description of the forms used to collect these data is available on the NACC website. Additional questionnaire and interview data that are unique to the Wisconsin ADRC are also collected. See Table 1 for a complete list of UDS and Wisconsin ADRC Forms, including NACC Form numbers. See the Wisconsin ADRC Data Dictionary for complete listing of data variables and their descriptions.
Cognitive and Psychological Variables: Cognitive testing includes the NACC battery and the Rey AVLT. In general, this standard cognitive battery is performed annually. Some additional psychological questionnaire data and cognitive test data are collected at the first annual follow-up visit (Year 2) from the middle-age cohorts. The battery is described in Table 1.
In addition to cognitive testing, the Wisconsin ADRC has three optional sub-studies. Outlined below, participants can choose to participate in any or all of these studies. The maximum time between a study visit (baseline or an annual) and CSF collection or MRI is six months. However, the two visits generally occur within two months of each other.
Neuroimaging Data are collected from eligible participants who agree to complete the optional substudy. Brain imaging is performed soon after a Clinical Core visit (Baseline or annual follow-up), and can be linked to variables collected at Core Visits. All scans are obtained in a fasting state, and prior to lumbar puncture (another, separate and optional sub-study) to reduce meningeal enhancement related to the lumbar puncture procedure. Neuroimaging data collected from Clinical Core participants include:
- Anatomical Scans: These are standard scanner sequences weighted for identifying and quantifying brain tissue health and volume. These include T1-weighted, T2 weighted, T2* weighted and diffusion weighted scans.
- Blood Flow Scans: Scans weighted for cerebral blood flow are obtained. These include spin labeling and phase contrast methods that measure intrinsic flow-related signal. No IV-contrast is administered.
- Functional Scans: Blood oxygen-level-dependent (BOLD) scans are also acquired to make inferences regarding brain activity. These scans involve acquiring images while the participant is at rest.
Laboratory and Clinical Data: Additionally, laboratory tests are performed and vitals signs collected annually from all participants. These are listed in Table 1. Also listed in Table 1 is a genetic test performed at Baseline. Specifically, participants’ Apolipoprotein E (ApoE) genotype is available.