Funded Pilots

Past Pilot Project Grants

Pilot Projects 2016-2017

The Wisconsin Alzheimer's Disease Research Center commends the following 2016-2017 award recipients for pilot research studies in Alzheimer's disease (AD) and related illnesses:

  • Reid Alisch, PhD, "DNA methylation age and gender in the Wisconsin Registry for Alzheimer's Prevention (WRAP)"
  • Matthew Jones, PhD, "Scavenging of neuroprotective neurosteroids by A-beta, and consequences for GABAergic inhibition"
  • Nicole Pulia, PhD, "Development of novel therapeutic interventions for patients with Alzheimer's disease and comorbid dysphagia"
  • Vikas Singh, PhD, "Multiscale analysis of brain connectivity and the interplay with molecular imaging markers in preclinical AD"
  • Nicole Werner, PhD, "HelpCareConnect: Design of a web-based mobile app for distributed informal caregiving"

Pilot Projects 2015-2016

The Wisconsin Alzheimer's Disease Research Center commends the following 2015-2016 award recipients for pilot research studies in Alzheimer's disease (AD) and related illnesses:

  • Erika W. Hagen, PhD, "Brain injury in relation to new-onset and long-duration sleep apnea exposure in older adults: A population-based study"
  • Sterling Johnson, PhD, "In-vivo tau imaging in Alzheimer's disease"
  • Katherine Kalil, PhD, "The role of tau phosphorylation in cytoskeletal dynamics mediating pre- and post-synaptic plasticity of normal and Alzheimer's human iPSC-derived cortical neurons"
  • William G. Schrage, PhD, "Vascular control of cerebral blood flow in middle-aged adults"

Pilot Projects 2014-2015

The Wisconsin Alzheimer's Disease Research Center commends the following 2014-2015 award recipients for pilot research studies in Alzheimer's disease (AD) and related illnesses:

  • Andrew L. Alexander, PhD, "Imaging Neuroplasticity in Mild Cognitive Impairment"
  • Rozalyn Anderson, PhD, "Impact of Aging and AD on Neuronal Energy Metabolism in the Mouse Hippocampus"
  • Jill Barnes, PhD, "Cerebral Vasoconstrictor Function and Autoregulatory Capacity in Exercise-Trained Humans: A Pilot Study"
  • Cara J. Westmark, PhD, "Testing Direct Effects of mGluR5 Inhibition on Sleep in an Alzheimer's Disease Mouse Model"

Pilot Projects 2013-2014

The Wisconsin Alzheimer's Disease Research Center commends the following 2013-2014 award recipients for pilot research studies in Alzheimer's disease (AD) and related illnesses:

  • Brad Christian, PhD, “Development and Translation of a Neuroinflammation Biomarker
  • Vincent Cryns, MD, “Caspase-cleaved Tau as a Biomarker in Alzheimer’s Disease
  • Robert Thorne, PhD, “Toward the Development of Noninvasive Immunotherapy for Alzheimer’s Disease:Intranasal Targeting of IgG to the Brain”

Pilot Projects 2012-2013

The Wisconsin Alzheimer's Disease Research Center commends the following 2012-2013 award recipients for pilot research studies in Alzheimer's disease (AD) and related illnesses:

  • Anita Bhattacharya, PhD, “iPSCs from Down Syndrome Individuals with Amyloid Load
  • Maritza Dowling, PhD, “Metric Equivalence and Comparability of the MMSE and MoCA Cognitive Tests and Impact on the Identification of Cognitive Impairment”
  • Dorothy Farrar-Edwards, PhD, “Development of an AD Prevention Program for African Americans
  • Ozioma Okonkwo, PhD, “Identification of Antecedent Biomarkers of Alzheimer’s Disease in Cerebrospinal Fluid using a Clinically Available Endophenotype”
  • Mariana Pehar, PhD & Luigi Puglielli, MD, PhD, “Involvement of p53 Activity in the Cognitive Decline that Accompanies Aging and Alzheimer’s Disease”

Pilot Project 2011-2012

The Wisconsin Alzheimer's Disease Research Center commends the following 2011-2012 award recipients for pilot research studies in Alzheimer's disease (AD) and related illnesses:

  • Sean Fain, PhD - Proposal to develop in vivo marker of brain metabolism, i.e. hyperpolarized 1-13C-pyruvate, using a mouse model
  • Michael Gitcho, PhD & Jeff Johnson, PhD - Proposal to clarify role of overexpression of a tau-like protein, TDP-43 in AD pathology, using mouse model and brain tissue
  • Li Lingjun, PhD - Proposal to derive and test drug-delivery potential of a modified N-acetyl-L cysteine molecule, which is a known antioxidant agent

Pilot Project 2010-2011

Three researchers were awarded Pilot Study Grants in the 2010-2011 grant year by the Wisconsin Comprehensive Memory Program to conduct studies related to memory and cognitive disorders such as Alzheimer’s disease (AD) and Mild Cognitive Impairment (MCI).

Congratulations to the following awardees of the pilot grant:

  • Gururaj Joshi, PhD & Jeff Johnson, PhD, "Role of Nrf2 in mouse models of Alzheimer's disorders"
  • Corinne Engelman, MSPH, PhD, "Genetic architecture of Alzheimer's-related functional and structural brain aging"
  • Georgia Malandraki, PhD, "Effects of sensory stimulation on neural activity and swallowing performance in patients with mild Alzheimer's disease"

Pilot Project 2008

The Wisconsin Alzheimer's Disease Research Center commends the following 2008 award recipients for pilot research studies in Alzheimer's disease (AD) and related illnesses:

  • Barbara B. Bendlin, PhD for her project entitled "Early Detection of White Matter Degeneration in People at Risk for Alzheimer’s Disease: Relationship to Vascular Risk and Memory Function"
  • Bradley Christian, PhD for his project entitled "PET Imaging the 5-HT1A System in MCI and AD"
  • Onofre T. DeJesus, PhD for his project entitled "PET Imaging Markers For Tau Protein"
  • Carey Gleason, PhD for her project entitled "A Mechanistic Examination of Falls Occurring in Patients with Mild Cognitive Impairment and Alzheimer’s Disease"
  • Bruce Hermann, PhD for his project entitled "Cognitive aging in chronic epilepsy"
  • Luigi Puglielli, MD PhD for his project entitled "An aging pathway controls Alzheimer's disease neuropathology"
  • Vikas Singh, PhD for his project entitled "Methods and tools for image based AD classification with evaluations on the ADNI dataset"
  • Joshua M. Thorpe, PhD, MPH for his project entitled "Barriers to Medical Care and Medication Adherence in Persons with Alzheimer’s Disease and Related Disorders"
  • Whitney Wharton, PhD for her project entitled "The Effect of Centrally Acting Antihypertensives on Individuals at Risk for Alzheimer's disease"

Pilot Project 2006

The Wisconsin Alzheimer's Disease Research Center commends the following 2006 award recipients for pilot research studies in Alzheimer's disease (AD) and related illnesses:

  • Cynthia Carlsson, MD, MS for her project entitled "Impact of Atorvastatin on Cerebral Perfusion and Endothelial Function"
  • Timothy Juergens, MD for his project "Autonomic dysfunction in subjects at risk of developing Alzheimer's disease"
  • Ronald Kalil, PhD for his project "Nestin positive neurons in the cholinergic basal forebrain and related areas"
  • James Malter, MD for his project "Characterization of a novel mouse model for the study of neurological diseases"
  • Michele Ries, PhD for her project "Posterior cingulate connectivity in individuals at risk for Alzheimer's disease"
  • JoAnne Robbins, PhD and Ianessa Humbert, PhD for their project "Swallowing physiology and Neurophysiology in Alzheimer's disease and Lewy Body Disease"
  • Randal Tibbits, PhD for his project entitled "Functional dissection of ATM-CREB signaling pathway in the nervous system"
  • Jerry Yin, PhD for his project "CREB-responsive transcription of APP"