This unique study uses positron emission tomography (or PET for short) brain scans to visualize neuronal synapse density, amyloid plaques, and neurofibrillary tangles. We will also obtain MRI data to investigate how these factors are affecting brain health. The study examines whether AD pathology affects the quantity of synapses, and whether loss of synapses over time is associated with cognitive decline. If you qualify for the study, we will ask you to complete three PET scans of your brain—one for amyloid, one for tangles, and one for synapse density (completion of an MRI scan may also be required) then repeat the scans two years later.
- Participant in the Wisconsin Alzheimer's Disease Research Center (ADRC) or the Wisconsin Registry for Alzheimer's Prevention (WRAP)
- 50 years of age and up