Open Studies

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Actively Recruiting Studies

If you are interested in learning more about any of the following studies at the Wisconsin Alzheimer's Disease Research Center, please contact the Study Coordinator listed.Color

Alzheimer's Disease Research Center Clinical Core Study

People who join this study attend a yearly visit with a study partner and undergo memory and thinking abilities evaluations. They also participate in other ADRC-affiliated studies.

We are currently recruiting:

  • People with Alzheimer's disease
  • People with mild cognitive impairment (MCI)
  • People age 45-65 with our without a partental history of AD

If you are interested in participating or learning more about the study, please contact Hector Salazar at (608) 265-0407.


Alzheimer's Disease Connectome Project

Are you experiencing memory problems or problems carrying out day-to-day activities because of issues with your memory or thinking? Is so, you may be eligible for a study at the University of Wisconsin School of Medicine and Public Health. The Connectome Project aims to make the most detailed measurements of brain networks to date in people with mild cognitive impairment (MCI) and Alzheimer's disease. The study involves visits to the University of Wisconsin-Madison campus and includes brain scans and blood labs. The Connectome Project is open to men and women between 55-90 years of age. You will need a study partner who can answer questions over the phone in order to participate. People with a diagnosis of major depression, multiple sclerosis, Parkinson's disease, stroke, traumatic brain injury, or epilepsy are not eligible for this study.

If you are interested in learning more, please call Mary-Elizabeth at (608) 262-7399.


Amyloid and Tau Imaging in Alzheimer’s Disease

The Wisconsin Alzheimer’s Disease Research Center (ADRC) and the Wisconsin Registry for Alzheimer’s Prevention (WRAP) at the University of Wisconsin-Madison are conducting a brain imaging research study to identify how Alzheimer’s disease develops. We use positron emission tomography (PET) to image amyloid plaques and neurofibrillary tangles. Studies such as this may identify ways to improve early detection and offer more accurate diagnosis. This is an add-on study to the ADRC Clinical Core and WRAP studies. This imaging study includes a wide range of participants from cognitively normal persons to those with mild cognitive impairment or dementia. We hope you will consider joining us for this next step in Alzheimer’s disease research.

Participants will be asked to complete two PET scans. The amyloid PET scan takes 75 minutes. The tau (neurofibrillary tangle) PET scan takes about 50 minutes after a 70-minute resting uptake period. All participants will be compensated $50 for each PET scan.

If you are interested in hearing more about the study, please contact Heather Shouel at (608) 262-2074.



The EXERT study is looking for participants to help researchers identify the right dose of exercise for people with mild memory problems. Participants who take part in this study will complete screening procedures on the phone and in the clinic. Once enrolled, participants will complete up to 10 outpatient visits to our research centers over a 20-month period. Clinic visits will include physical exam, blood collection, cognitive testing, brain imaging and optional lumbar puncture.

Participants must be 65-89 years old with mild memory loss or diagnosed with Mild Cognitive Impairment, in otherwise good health, have no metal in the body, and must be able to exercise at a participating local YMCA four times per week for 18 months (duration of study). Participants must also have someone who knows them well and who would be willing to answer questions about the participant in the clinic or over the phone. Eligible adults must be willing to participate in either the stretching/balance/range-of-motion exercise group or the aerobic exercise group.

If you are interested in participating or learning more about the study, please contact the coordinator, Max Gaitán, via email at


Brain Amyloid and Vascular Effects of Eicosapentaenoic Acid (BRAVE-EPA)

The purpose of this research study is to evaluate if EPA, an omega-3 fatty acid, improves biomarkers of Alzheimer's Disease, and thinking abilities in middle-aged, cognitively healthy Veterans at risk for this common form of dementia.

We are looking for veterans aged 50-70 years old with normal memory and thinking abilities who have a parent with Alzheimer's disease.  The study requires 9 visits spread over 18 months at the William S. Middleton Memorial Veterans Hospital and the University of Wisconsin in Madison, WI.

If you are interested in participating or learning more about the study, please contact the coordinator, Elena Beckman at (608) 256-1901 ext.11199 or email


Alzheimer’s Disease Neuroimaging Initiative (ADNI)

The Alzheimer’s Disease Neuroimaging Initiative, also known as ADNI, is a historic study of brain aging looking to help change the future. ADNI’s unprecedented approach to research is intended to encourage new investigation and to increase the pace of discovery in the race to prevent, treat and one day cure Alzheimer’s disease. Poor memory is often viewed as a simple sign of getting older, complicating our understanding and treatment of Alzheimer's disease. For more than a decade, ADNI researchers have worked to better understand the disease and its progression in a way that will help the development of future treatment options. We are looking for volunteers.

You may be able to help if you are 55 to 90 years of age and ...

  • Are in good general health
  • Are cognitively normal, have Mild Cognitive Impairment (MCI) or have been diagnosed with mild dementia due to Alzheimer’s disease
  • Are willing and able to undergo in-clinic assessments, memory testing and other test procedures
  • Have a study partner who can accompany you to all clinic visits

This is a free study. No experimental medication will be involved.

If you are interested in participating or learning more about this study, please contact Christina Chin, (608) 262-2071.


Mission AD Study (sponsored by Eisai & Biogen)

The Wisconsin Alzheimer’s Disease Research Center is currently recruiting participants for a clinical research study investigating whether Elenbecestat (E2609, a BACE inhibitor) is superior to placebo in slowing disease progression (disease getting worse) in subjects age 50-85 years old with early Alzheimer’s disease. This research will also continue to study if Elenbecestat is safe and well tolerated.

The study involves coming to the University of Wisconsin-Madison for 13 study visits. Each visit will last between 2 to 6 hours. Some of the study procedures include blood draws, questionnaires, physical and neurological exams, MRI scans, PET scans, and electrocardiograms. You might need to make more than one trip in visits involving brain imaging: Magnetic Resonance Imaging (MRI), Positron Emission Topography (PET) scan or Cerebral Spinal Fluid (CSF) collection.

If you would like to learn more about the study, please contact Zak Zugin at (608) 265-6347.


MIND Study (sponsored by ATRI/NIA)

The Memory Improvement Through Nicotine Dosing (MIND) study currently being conducted by local researchers at the Wisconsin ADRC is testing whether nicotine in patch form is effective in improving memory and functioning in adults diagnosed with MCI.

Currently, there is no FDA-approved treatment to alleviate MCI symptoms or to prevent progression to Alzheimer’s disease. However, since nicotine stimulates an area in the brain known to be important for thinking and memory, scientists believe it can be an effective treatment for adults with MCI.

This study seeks to determine if nicotine can improve attention and memory over a sustained period of time in older adults with MCI. MIND is seeking healthy, non-smoking adults, age 55+ who have noticed changes in their memory or whose family members have noticed changes. Those who meet the study qualifications will be placed on either daily nicotine or placebo patches.

If you would like to learn more about the study, please contact Zak Zugin at (608) 265-6347.


Join the Wisconsin ADRC Registry

New studies start frequently at the Wisconsin ADRC, and we're looking for men and women volunteers. In order to match interested persons with future studies, the Wisconsin ADRC has created a research database—the Wisconsin ADRC Registry—to hold the names and eligibility information of potential volunteers. When new studies become available, we will use the Wisconsin ADRC Registry to identify persons who may qualify for the new opportunity.

As the future holds limitless possibilities for clinical trial developments, anyone who is interested in contributing to the advancement of memory research may join the Wisconsin ADRC Registry. You do not have to be experiencing memory problems or have a memory diagnosis to join the Registry. Persons with or without memory problems, regardless of family history, may join. Also, joining the Wisconsin ADRC Registry does not commit you to participating in future studies. If you are contacted about a new study, you may decline to participate in that study and still remain in the Registry to receive information about other future studies.

To join the Registry, you will be asked to complete a phone questionnaire that will review your personal and family medical history, your medication use, and if present, your current memory symptoms in detail. Wisconsin ADRC staff may contact you approximately once annually to verify that your medical history and medication information remain up-to-date.

If you are interested in participating or learning more about the study, please contact Hector Salazar at (608) 265-0407.


updated 8/29/2018