For scientists interested in ADRC resources, please fill out the ADRC Application for Resources.
For scientists interested in WRAP resources, please fill out the WRAP Application for Resources.
For internal candidates requesting data or images for a project originating within Wisconsin ADRC or WRAP, please use the UP Protocol Application for Resources.
The Wisconsin Alzheimer’s Disease Research Center (ADRC) is committed to sharing resources with internal and external investigators. View a list of our Resources and Services.
Our center partners with the Wisconsin Registry for Alzheimer’s Prevention (WRAP). WRAP is a longitudinal cohort study funded by the National Institute of Health. It has enrolled more than 1,500 middle-aged adult children with parents with Alzheimer’s disease.
Your resource request(s) will be taken into consideration by the applicable Science Executive Committee. You will be notified within 4 to 6 weeks regarding the status of your application. The committee will not provide a written evaluation of proposals. A letter indicating the committee’s decision to support or not support the proposed request will be provided to the applicant, along with any special instructions and/or requirements that must be met before resources will be released.
If you have any questions prior to your electronic submission, please contact ADRCrequest@medicine.wisc.edu.
Requests going to Wisconsin ADRC’s Executive Committee
The ADRC Executive Committee must review requests to recruit eligible research subjects from the Wisconsin ADRC Clinical Core to obtain archived data or collect tissue or stored bio specimens. The committee meets the second Wednesday of the month. Applications must be submitted no later than two weeks prior to the meeting.
To apply for ADRC data, tissue, or permission to recruit eligible research subjects from the Wisconsin ADRC Clinical Core, please fill out the electronic ADRC Resource Request Application. (For internal candidates requesting data or images for a project originating within the Wisconsin ADRC or WRAP, click here for the UP Protocol Application for Resources.)
You will be asked to upload your biosketch and provide a brief summary of your research project. If you have any questions prior to your electronic submission, please contact ADRCrequest@medicine.wisc.edu.
Following your submission, additional documentation may be required based on the nature of your request.
Executive Committee’s determination
The committee will not provide a written evaluation of proposals. A letter indicating the committee’s decision to support or not support the proposed request will be provided to the applicant, along with any special instructions and/or requirements that must be met before resources will be released.
Review and Post-Review Process
The Executive Committee members will review proposals at their monthly meeting. The ADRC administrator will ensure that appropriate core leaders are present for the meeting in order to have a quorum for scientific review of each proposal. NIH guidelines for grant review will be utilized for review of all proposals.
Post Review Process
A letter will be sent to the investigator(s) of the proposed research indicating whether committee approval was granted and any steps that must be taken before resources will be released. In addition to specific requests from the committee, the investigator must provide:
- Signed Agreements Document
- Evidence of IRB approval/exemption status
- Material Transfer Agreement (if applicable)
Other post review matters:
- Annual review of progress reports and expiration of approvals
- Distribution of resources
Investigators whose requests for resources are approved must sign the agreements document that covers the following:
- Acknowledging the Wisconsin ADRC. Formally acknowledge the Wisconsin ADRC’s contribution to the project (e.g., in the Acknowledgment section of a manuscript). Please indicate the specific Cores that provided support for the project. For example, “The authors would like to acknowledge the clinical and neuropathology diagnostic support provided by the Wisconsin ADRC’s Clinical, Neuropathology and Biomarkers Cores, and biostatistical support provided by the Data Management and Biostatistics Core.”
- Reporting the Wisconsin ADRC grant number in publications. Include NIH-NIA grant number (P30AG534255) in all publications (manuscripts and abstracts) and presentations related to work using Wisconsin ADRC resources.
- Obtaining a PubMed Central ID (PMCID) number. For all publications resulting from work using Wisconsin ADRC resources, investigators must obtain a PMCID.
- Providing Annual Progress Reports. Submit an annual progress report every year after the resource request is fulfilled until the study is completed. Approvals not reviewed annually are considered expired. Click here for the instructions on how to complete this form. These reports should be sent to ADRCrequest@medicine.wisc.edu.
Annual review of progress reports and expiration of approvals
The Wisconsin ADRC Executive and Tissue Committees will review Annual Progress Reports during their monthly meetings. The committees reserve the right to rescind approval of previously approved requests. This is most likely to occur if the resources requested are severely limited in quantity. Approved projects not reviewed on an annual basis will be considered expired.
Distribution of Resources
Once all requested documents are received by the ADRC, the investigator will coordinate with the Data Service Liaison to transfer approved data.
Requests for samples will be filled once required documents and/or approvals are provided to the ADRC. Samples will be distributed based on availability at the time documentation is complete, and not based on availability at the time of approval.
Requests for Archived Data: Cognitive Data, Neuroimages, Questionnaire Data
Applications for archival data must follow the defined application process. Data will be coded; thus, it is possible that some specific information may not be available for certain age groups. For example, we may not release specific age, ethnicity and city of residence for individuals over the age of 89, as it could be possible in some cases to uncover a participant’s identity with this information. For a description of the information that is available, click here.
Institutional Review Board Instructions
All projects proposing to use Wisconsin ADRC resources must have approval or exemption status from an Institutional Review Board (IRB) before the resources will be released. Instructions and applications for approval and exemptions from a University of Wisconsin Human Subjects Committee can be found at your institution's IRB website. Investigators must receive approval from the ADRC executive committee before applying to an IRB. No resources will be released until approval has been obtained by the prospective investigator and given to the ADRC. Please contact ADRCrequests@medicine.wisc.edu.
In order for an IRB to consider a project exempt from review, data collection cannot be ongoing. Data collection for the Wisconsin ADRC’s Clinical Core is ongoing; however, if an investigator indicates that only data collected during a specified and past period will be requested, the project may still be categorized as exempt. See the Code of Federal Regulations, Part 46 for more details. Non-exempt status is determined by an IRB, not by the investigator.
Requests to Recruit ADRC Clinical Core Participants
IRB approval must be secured before any recruitment activities can be initiated. Applications to recruit Clinical Core volunteers must include a Procedures Report, which will outline all interventions, procedures and/or drugs administered at each visit. For a description of the research participants who are open to recruitment, click here. dsaVCXZewq
Initial correspondence with potential subjects must originate from the Wisconsin ADRC. Neither names nor contact information will be released to investigators (not on the ADRC protocol). You may be asked to provide funding for administrative support to complete aforementioned mailings. The ADRC will send out the recruitment letter that you get approved by your IRB.
All investigators recruiting ADRC participants must provide the ADRC with a copy of the UW IRB approved protocol and consent form(s), along with a copy of the approval letter, prior to the initiation of the study. Multi-year studies must forward copies of continuing review approvals.
Please include language in your consent form that permits the future use of the data you collect (e.g., “Your data may be used by the research team now and in the future to answer questions about health concerns, memory, and thinking.").
Investigator orientation to recruitment of ADRC subjects
Before any recruitment with ADRC subjects can begin, the investigator and any research coordinator who may be in contact with subjects will receive an orientation to procedures for contact and interaction with subjects. This orientation includes how they will receive subject information, the "dos and don’ts" of scheduling and testing ADRC subjects. This orientation will be conducted by the Wisconsin ADRC Clinical Research Program Manager and Regulatory Specialist. To request an orientation contact Michelle Wahoske, MS, Clinical Research Program Manager.
Requests for Stored Biological Samples: Plasma, Serum, Cerebrospinal Fluid, Brain Tissue
Investigators who request tissue must provide documentation of IRB approval or exemption status. Samples will be coded. A limited amount of demographic data linked to each sample can be provided (i.e., diagnosis, age at death, and gender of the person from whom the sample was obtained). Requests for additional data will need to be reviewed and approved by either the Tissue or Executive Committee. The investigator must specify what additional demographic data are needed at the time the application is submitted, and not at the time the samples are distributed. You may only utilize these samples for the purpose for which you were approved. Destroy or return unused samples as indicated in your approval letter. Investigators are responsible for all costs related to shipping/delivery of the requested samples.
Data Sharing Policies
The Wisconsin ADRC follows the NIH Data Sharing Policy. Similarly, we ask that investigators using ADRC resources share data with the ADRC. For example, data collected directly from Clinical Core participants, or data derived from procedures performed with archived data, or stored samples (e.g., genotype or assay findings) can be transferred to the Data Management and Biostatistics Core Resource Liaison (Rick Chappell, PhD) for inclusion in the ADRC data repository.
As noted in the preceding sections, an investigator proposes to obtain data or subjects from the Wisconsin ADRC, (s)he must have a discussion about the proposed project with the Core Liaison before submission to the review committee(s). A discussion of Data Sharing will occur during that meeting. Documentation of what data will be shared or not shared will be included in the Application for Resources.
Again, the Wisconsin Alzheimer’s Disease Research Center (ADRC) encourages applications requesting access to our center’s various resources. If you have questions are would like guidance on applying for resources, feel free to contact the Executive Administrator, Hanna Blazel, MS, CCC-SLP.