Two copies of APOE4 gene may indicate genetic form of Alzheimer's

Stock photo of a DNA strand

Sterling Johnson, PhD, is co-author of a study published in the journal Nature Medicine on May 6, 2024. The study found that individuals who carry two copies of the APOE4 gene are likely to face symptoms and develop Alzheimer's disease at an earlier age. The discovery is expected to influence future research, diagnosis and approaches to treating the disease.

Learn more: "WRAP data used in study finding a distinct, genetic form of Alzheimer’s disease."


APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease” was published by Nature Medicine on May 6, 2024.

Genes known to increase the risk of Alzheimer’s may actually be an inherited form of the disorder, researchers say” appeared on on May 6, 2024.

People with two copies of a risk gene have genetic form of Alzheimer's, scientists say” appeared on on May 6, 2024.

Study Suggests Genetics as a Cause, Not Just a Risk, for Some Alzheimer’s” appeared in The New York Times on May 6, 2024.

"Study defines major genetic form of Alzheimer’s disease" appeared on the National Institute of Aging website on May 24, 2024.

Updated May 20, 2024, June 10, 2024.